The Gene Box
For doctors

For doctors: order Calibrate PGx (249 drugs) or a Clarity exome

There are two tests you can order for a patient:

  • Calibrate PGx: pharmacogenomics. Calibrate reports drug-gene interactions across 249 drugs. You can order it on its own.
  • Clarity: clinical exome sequencing, for suspected rare disease.

Both reports are written for the referring doctor. They are decision-support, not diagnosis, so you keep the final say.

Contact us to order

What you can order

Test
Calibrate PGx (249 drugs)
What it's for
Calibrate reports drug-gene interactions across 249 drugs
Who it suits
Patients starting, or not responding to, drugs with known gene-drug interactions, such as clopidogrel and warfarin
Details
/calibrate
Test
Clarity: rare disease exome
What it's for
Whole exome sequencing, with variants classified using ACMG/AMP criteria; trio (patient + both parents) available
Who it suits
Suspected monogenic or rare disease, developmental delay, when previous tests haven't given an answer

Clarity is the exome. PGx is ordered through Calibrate.

Drug-gene guides

How to order

  1. 1Get in touch: contact us to order, and say whether you want Calibrate, Clarity, or both.
  2. 2Share the clinical details: patient details, clinical indication, relevant history and current medicines (for Calibrate), and family history or pedigree (for Clarity).
  3. 3Get informed consent: the patient (or their parent or guardian) gives written consent before the sample is collected. For a trio, each parent gives consent for their own sample.
Contact us to order

Order Calibrate

Calibrate is ordered on its own. It doesn't need an exome. When you get in touch, tell us the patient's current and planned medicines.

Order Clarity

For a Clarity exome, add a clear clinical summary (HPO terms if you use them), the relevant personal and family history, and say whether you want a trio.

Samples

Trio
Calibrate PGx
n/a
Clarity exome
Yes. One sample each from the patient and both parents

Consent

  • Written informed consent is needed before every test.
  • Written consent covers: what the test looks at; possible results (positive, negative, uncertain); for exome, the chance of secondary findings (results unrelated to the reason for testing, such as an actionable hereditary cancer or heart condition) and the patient's choice about whether to receive them; and how the data is stored and used.
  • For minors, a parent or guardian gives consent.

What the report gives you

  • Calibrate: it reports drug-gene interactions across 249 drugs.
  • Clarity: reportable variants classified using ACMG/AMP criteria, with the evidence for each.

Hospitals and labs

To offer these tests under your own name, see /solutions/hospitals and /solutions/labs, or book a walkthrough at /demo.

FAQ

Where can a doctor in India order a PGx test?
From The Gene Box. Order Calibrate, our PGx test, on its own. Contact us at /contact. Calibrate reports drug-gene interactions across 249 drugs.
Do I need to order an exome to get PGx results?
No. You can order Calibrate on its own. Clarity (clinical exome) is a separate test.
How do I order a genetic test for my patient?
Contact us to order, tell us which test you want and the clinical details, and get the patient's written consent before the sample is collected. The steps are listed above.
Which exome tests can I order?
Clarity covers whole exome sequencing for suspected rare disease, with trio analysis available. Variants are classified using ACMG/AMP criteria.
Who interprets the results?
The Gene Box provides an interpreted report as decision-support. The referring doctor makes the diagnosis and treatment decisions.