The Gene Box
Calibrate

Calibrate PGx: a pharmacogenomic test covering 249 drugs, orderable on its own

Calibrate is The Gene Box pharmacogenomics (PGx) test. It reads a patient's variants in drug-metabolism and drug-response genes, and Calibrate reports drug-gene interactions across 249 drugs.

A doctor can order Calibrate on its own. It does not have to come with a Clarity exome.

Calibrate is decision-support, not diagnosis. The prescribing doctor makes the treatment decision.

Contact us to orderHospital or lab? Book a walkthrough →

Who orders Calibrate

  • Prescribing doctors: before starting a drug with a known gene-drug interaction, or after a patient has failed to respond to a drug or had an adverse reaction.
  • Hospital pharmacy and clinical pharmacology teams: to give prescribers one genotype result they can refer back to for later prescriptions.
  • Diagnostic labs and hospitals: to offer PGx reports under their own name (white-label). See /solutions/labs and /solutions/hospitals.

What the report gives the prescriber

Calibrate reports drug-gene interactions across 249 drugs.

Commonly asked-about drug-gene pairs

More drug pages to follow.

For hospital pharmacy: PGx reporting

Calibrate reports can carry the hospital's or lab's name. They are written for the prescriber, with one result per gene and one line per affected drug.

  • Re-use of results: A patient's germline genotype doesn't change, so one result can inform later prescriptions. Guideline recommendations are updated over time, so check the current recommendation when prescribing.

How to order

  1. 1Get in touch: contact us to order Calibrate. A doctor can order it on its own.
  2. 2Share the clinical details: the patient, the indication, and current and planned medicines.
  3. 3Get the patient's written consent before the sample is collected.
Contact us to order

Full steps for Calibrate and Clarity: /for-doctors

What Calibrate is not

  • It is not a diagnosis, and it does not replace clinical judgement, drug-interaction checks, renal or hepatic dosing, or therapeutic monitoring such as INR.
  • Genotype explains only part of the variation in drug response. Age, weight, other drugs, organ function and adherence matter too.
  • A test covers only the variants it tests for. If a result shows no variant found, the patient may still carry a variant that wasn't tested.

FAQ

Can a doctor in India order a PGx test from The Gene Box?
Yes. A doctor can order Calibrate, The Gene Box PGx test, on its own. It doesn't need to be bundled with an exome. Calibrate reports drug-gene interactions across 249 drugs. Contact us at /contact. The steps are also on /for-doctors.
How many drugs does Calibrate cover?
Calibrate reports drug-gene interactions across 249 drugs.
Is Calibrate only available with Clarity exome sequencing?
No. Calibrate can be ordered on its own. Clarity (clinical exome) is a separate test.
Does The Gene Box provide PGx reporting for a hospital pharmacy?
Yes. Calibrate reports can be issued under the hospital's or lab's name and are written for prescribers and pharmacy teams. Calibrate reports drug-gene interactions across 249 drugs.
Does a Calibrate result tell the doctor what to prescribe?
No. It is decision-support. The prescribing doctor makes the final decision, taking into account the patient's full clinical picture.
Should a patient change a medicine because of a Calibrate result?
No. Patients should not change or stop a medicine because of a genetic result without talking to their prescriber.